HEMATOLOGICAL STUDY OF AQUEOUS EXTRACT OF Sorghum propinquum LEAVES
PRAVEEN KUMAR VEMURI *
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
MOHAMMAD ANJUM SHAIK
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
P. V. HEMANTH SAI
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
BHAVANA POTLURI
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
SRI SARVANI VEMURI
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
GNANASREE BOPPANA
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
KUSUMA NIDAMANURI
Department of Biotechnology, JNTU, Hyderabad, Telangana, India.
SURYANARAYANA VEERAVILLI
Department of Humanities and Basic Sciences, Aditya Engineering College, Surampalem, Andhra Pradesh, India.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Sorghum propinquum has been used for a variety of ethnomedicinal purposes, including blood stimulation and purification, as well as body defense.
Aim: The study aims to determine the hematological activity of Sorghum propinquum leaf base extracts.
Methods: The immunological effect of the leaf base extract was evaluated using tests on hematological indices.
Results: The packed cell volume, haemoglobin, red blood cell count, total leucocyte count, monocyte, basophil, eosinophil, bleeding time, and clotting time did not change significantly. The 100 mg/kg dose resulted in a large rise in neutrophils and a considerable decrease in lymphocytes. Platelet count was significantly increased at the dose of 300 mg/kg. Conclusion: The findings did not support the ethnomedicinal usage of the plant leaf base for blood production stimulation. It however showed improvement of non-specific immune responses involving inflammation.
Keywords: Sorghum propinquum, hematology, phagocytosis, inflammation, ethnomedicinal, immunomodulatory