STACHYIBOTRUS TOXIC MICROSCOPIC FUNGUS LOW MOLECULAR METOBOLITES

Main Article Content

LUKHMON KAMOLOV
https://orcid.org/0000-0001-7316-0425
SEVARA TOJIYEVA
SHUXRAT XASANOV
ELYOR BERDIMURODOV
ORIF AXMEDOV

Abstract

Filtered culture fluids of the Stachybotrys chartarum strain were exhaustively extracted with ethyl acetate. The isolated red residue was subjected to column chromatography (silica gel) with gradient elution, resulting in 2 different fractions. The opposite TLC of fraction 1 yielded a small amount of a mixture of known stachybotrolide compounds. These molecules exhibited chromatographic and spectroscopic properties similar to standard samples. Fraction 2 consisted of a crystalline material that showed the same parameters of 1H and 13C as the parameters of stachibotrin, a derivative of driman's sesquiterpenoid. The structure proposed for this compound was based on spectroscopic data and no indication of the configuration of stereogenic carbon atoms was obtained. In order to characterize this metabolite, an X-ray diffraction study of a single crystal was performed. The fungus was produced mainly stachybotrys fully characterized derived sesquiterpenoid of dromana.

Keywords:
Stachybotrys chartarum, Stachybotrys alternans, stachybotrys lobulata type, chromatographic, fungi, stachybotriotoxins, staxibotrin, staxibotrolid

Article Details

How to Cite
KAMOLOV, L., TOJIYEVA, S., XASANOV, S., BERDIMURODOV, E., & AXMEDOV, O. (2021). STACHYIBOTRUS TOXIC MICROSCOPIC FUNGUS LOW MOLECULAR METOBOLITES. PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY, 22(35-36), 50-61. Retrieved from https://www.ikprress.org/index.php/PCBMB/article/view/6301
Section
Original Research Article

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