WELL-DEVELOPED NANOSTRUCTURE INCORPORATED WITH Euphorbia umbellata EXTRACT INTO A UNIQUE FORM WITH GREATER BIOCOMPATIBILITY
ALAA A. OMAR *
Biochemistry Department, Faculty of Agriculture, Cairo University, Cairo, Egypt.
SHERIF H. AHMED
Biochemistry Department, Faculty of Agriculture, Cairo University, Cairo, Egypt.
YASMIN E. ABDEL MOBDY
Entomology and Pesticide Department, Faculty of Agriculture, Cairo University, Cairo, Egypt.
HASSAN A. AMRA
Food Toxicology and Contaminants Department, National Research Centre, Cairo, Egypt.
EMAM A. ABDEL-RAHIM
Biochemistry Department, Faculty of Agriculture, Cairo University, Cairo, Egypt.
*Author to whom correspondence should be addressed.
Abstract
The study demonstrated a combination of Polysaccharide-Based Nanoparticles with Euphorbia umbellata (Pax) Bruyns extract, Euphorbiaceae, into a unique form. The composite nanoparticles were prepared by using two biocompatible polymers, alginate (ALG) and chitosan (CS), by ionotropic pre-gelation followed by polycationic cross-linking. Nanoformulations were studied aiming future applications of this new material as medicine. In order to investigate potential interactions between ALG/CS and the extract, physicochemical characterization was performed by transmission electron microscopy (TEM), scanning electron microscopy (SEM), particle size and zeta potential, Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). The release profiles of phenolic compounds from loaded alginate/chitosan nanoparticles (ALG/CS-NPs) were evaluated using quantification method.The changes can be attributed to chemical interactions that occurred between the structure of the ALG/CS and the phenolic compounds present in the studied extract.
Keywords: Euphorbia umbellata (Pax) Bruyns, polysaccharide-based nanoparticles, polymers, nanoformulations