COMPREHENSIVE REVIEW ON ANTICARCINOGENIC EFFECT OF ABRIN
. AISHWARYA
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab -144411, India
VIJAY CHOPRA
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab -144411, India
AMRITPAL SINGH
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab -144411, India
MANISH VYAS *
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab -144411, India
NAVNEET KHURANA
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab -144411, India
NEHA SHARMA
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab -144411, India
PRANAV KUMAR PRABHAKAR
School of Allied Medical Sciences, Lovely Professional University, Phagwara, Punjab -144411, India
MANISH GUPTA
Mittal School of Business, Lovely Professional University, Phagwara, Punjab -144411, India
PRAMOD YADAV
Department of Rasashastra & Bhaishajya Kalpana, All India Institute of Ayurveda, New Delhi-110076, India
P. K. PRAJAPATI
Department of Rasashastra & Bhaishajya Kalpana, All India Institute of Ayurveda, New Delhi-110076, India
*Author to whom correspondence should be addressed.
Abstract
Background: Abrin is a type of ribosome-inactivating protein that inhibits eukaryotic protein synthesis which leads to apoptosis and cell death. Abrin is isolated from the plant Abrus precatorius L. (A. precatorius) it is a valuable plant from the family Fabaceae. It is commonly known as Gunja or Jequirity, it is found easily throughout India mainly Himalaya to Southern India and Ceylon. Abrin is the compound that provides toxicity to the plant.
Objective: A. precatorius has many essential chemical compounds one of them is abrin, which is highly potent for the treatment of cancer. The objective of this review is to provide a retrospective study based on its anti-cancer potential.
Results: Recent studies of Abrin are based on the characterization, and pharmacological evaluation. Abrin possesses significant anti-cancer, anti-tumor, apoptosis, and cytotoxic activities against various cancer cell lines.
Conclusion: The present review summarizes the anti-cancer potential of Abrin. However, extensive research is required to establish it as a potent chemotherapeutic agent.
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References
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