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Urinary Tract Infection has been recognized second most common infection after respiratory infection and is most frequent in women, accounting for nearly 60% of overall UTIs. Caused by single bacterial species E. coli, which is the most frequently infecting organisms. We undertook this study to know the prevalence of MDR E. coli among various urine samples and to find out antibacterial activity of different herbal extracts against these resistance strains. Out of 40 samples 9 isolates of E .coli (22%) were recovered, which were considered for study. Among these 9 E. coli isolates, 2 (28.6%) were found multiple drug resistant (MDR). The isolates showed high levels of resistance to Amoxycilin (AMX25), Oxacilin (OX1), Ceftazidime (CAZ30) and Ceftriaxone (CTR30). Nine plant species were screened for anti MDR activity and out of 9 plants the maximum zone of inhibition was observed in the aqueous extract of Terminalia chebula (22 mm) & Callistemon (22 mm)] which were found more potent than the previous studies. In conclusion, the prevalence of MDR Producers at our study was lower in comparison to the prevalence reported from other studies. The high rate of resistance in bacteria for antibiotics need alternative drug line to control UTI.
Geetha RV, Roy A, Lakshmi T. Nature’s weapon against urinary tract infections. International Journal of Drug Development and Research. 2011;3(3):85-100.
Wullt B. The role of P. fimbriae for Escherichia coli establishment and mucosal inflammation in the human urinary tract. International Journal of Antimicrobial Agents. 2002;21:605-21.
Eryılmaz M, Bozkurt ME, Yildiz MM, Akin A. Antimicrobial resistance of urinary Escherichia coli isolates. Tropical Journal of Pharmaceutical Research. 2010;9(2).
Kariuki S, Revathi G, Corkill J, Kiiru J, Mwituria J, Mirza N, Hart CA. Escherichia coli from community-acquired urinary tract infections resistant to fluoroquinolones and extended-spectrum beta-lactams. The Journal of Infection in Developing Countries. 2007;1(03):257-262.
Miller LG, Tang AW. Treatment of uncomplicated urinary tract infections in an era of increasing antimicrobial resistance. In Mayo Clinic Proceedings. 2004;79(8): 1048-1054.
Shaikh D, Ashfaq S, Shaikh K, Shaikh M, Naqvi BS, Mahmood ZA, Majid R. Studies on resistance/sensitivity pattern of bacteria related with urinary tract infections. Medical Jornal of Islamic World Academy of Sciences. 2005;15:129-33.
Nisha J, Muthu Kumar NJ, Visweswaran S, Anbu N, Banumathi V. In-vitro evaluation of anti-microbial potential of Traditional siddha formulation Seenthil chooranam against uropathogen by disc-diffusion technique. World Journal of Pharmaceutical Research. 2019;8(1):1067-1075.
Oladosu SA, Coker AO, Nwaokorie F, Olaniran O, Olawale JT, Oyetoke OO, Awoyeni EA. Antibacterial effects of Phyllantus amaruson urinary tract pathogens. International Clinical Pathology Journal. 2019;7(1):1‒10.
Kumar A, Mazumdar RS, Dhewa T. Biological synthesis of silver nanoparticles by using Viola serpens extract. Asian Pacific Journal of Tropical Disease. 2016; 6(3):223-226.
Kumar A, Mazumdar RS, Dhewa T. In vitro efficacy of biosynthesized AgNPs against Streptococcus mutans causing dental plaque formation. Journal of Scientific Industrial Research. 2018;77(4): 225-228.
Hasan AS, Nair D, Kaur J, Baweja G, Deb M, Aggarwal P. Resistance patterns of urinary isolates in a tertiary Indian hospital. Journal of Ayub Medical College Abbottabad. 2007;19(1):39-41.
Chitemerere TA, Mukanganyama S. In vitro antibacterial activity of selected medicinal plants from Zimbabwe. The African Journal of Plant Science and Biotechnology. 2011;5(1):1-7.
Hassan W, Kazmi SZ, Noreen H, Riaz A, Zaman B. Antimicrobial activity of Cinnamomum tamala leaves. Journal of Nutritional Disorders & Therapy. 2016; 6(2):2161-0509.