EFFICACY OF PHYTOCHEMICALS FROM GUAVA (Psidium guajava) LEAF AGAINST HELICOBACTER PYLORI CAUSING ULCER: AN In silico ANALYSIS
BARSHA NAYAK
Centurion University of Technology and Management, Odisha, India.
LOPITA MISHRA
Centurion University of Technology and Management, Odisha, India.
P. K. PUSTY
Centurion University of Technology and Management, Odisha, India.
K. V. D. PRAKASH
Centurion University of Technology and Management, Odisha, India.
DIPANKAR BHATTACHARYAY *
Centurion University of Technology and Management, Odisha, India and Go to Market Laboratory, Gram Tarang, Odisha, India.
*Author to whom correspondence should be addressed.
Abstract
Phytochemicals from Psidium guajava plant extract can cure Ulcer. It is caused by Helicobacter pylori. This objective of the study is to identify the phytochemical of Psidium guajava capable of curing Ulcer. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that p-cymene can effectively deactivate the dihydrofolate reductase enzyme thereby interrupting the life cycle of the organism.
Keywords: Phytochemical, Psidium guajava, Helicobacter pylori, ulcer