In silico ANALYSIS OF PHYTOCHEMICALS FROM Coriandrum sativum AGAINST MEASLES
SWATIPRAVA PANDA
Centurion University of Technology and Management, Odisha, India.
GEETANJALI RANA
Centurion University of Technology and Management, Odisha, India.
JOGESH KUMAR NAYAK
Centurion University of Technology and Management, Odisha, India.
IPSITA MISHRA *
Centurion University of Technology and Management, Odisha, India.
DIPANKAR BHATTACHARYAY
Centurion University of Technology and Management, Odisha, India.
*Author to whom correspondence should be addressed.
Abstract
Phytochemicals are non-nutritive compounds obtained from plants. It has been reported that Coriandrum sativum plant extract is used to cure Measles. The plant extract contains different phytochemicals. Measles is caused by the Measles virus. One of the key enzymes involved in its biochemical pathway is fatty acid degradation. The molecular docking of the phytochemicals with the enzyme was studied using Biovia Discovery Studio. The strength of the interaction was evaluated based on -CDocker energy and -CDocker interaction energy. High positive values for both the parameters indicated that out of different phytochemicals β-myrcene, Camphor, Geraniol, Geranyal-acetate, Petroselinicacid can effectively deactivate the enzyme thereby interrupting the life cycle of Measles Virus.
Keywords: Phytochemical, biovia, discovery studio, Coriandrum sativum, measles virus.