In silico ANALYSIS OF PHYTOCHEMICALS FROM Foeniculum vulgare AGAINST CONJUNCTIVITIS
SHARBANI BAHALI
Centurion University of Technology and Management, Odisha, India.
SUNANYA DAS
Centurion University of Technology and Management, Odisha, India.
IPSITA MISHRA
Centurion University of Technology and Management, Odisha, India.
DIPANKAR BHATTACHARYAY *
Centurion University of Technology and Management, Odisha, India.
*Author to whom correspondence should be addressed.
Abstract
Phytochemicals are non-nutritive compounds obtained from plants. It has been reported that Foeniculum vulgare plant extract is used to cure Conjunctivitis. The plant extract contains different phytochemicals. Conjunctivitis is caused by Hemophilus Influenza. One of the key enzymes involved in its biochemical pathway is shikimate dehydrogenase. The molecular docking of the phytochemicals with the enzyme was studied using Biovia Discovery Studio. The strength of the interaction was evaluated based on -CDocker energy and -CDocker interaction energy. High positive values for both the parameters indicated that out of different phytochemicals behenic acid and caproic acid can effectively deactivate the enzyme thereby interrupting the life cycle of the disease.
Keywords: Phytochemical, biovia, discovery studio, Foeniculum vulgare, hemophilus influenza.