Main Article Content



Burn injury has been one of the leading causes of accidental death in the world.  Thousands suffer from long-term consequences from the lack of effective first-aid treatment.  Many commercial burn lotions are not effective, as claimed. So, it should be an alarming issue for developing a burn injury that could alleviate the initial damages to the burn areas.

Burn skins have three acute excruciating problems such as pains, blisters, and skin infections.

The objective of the study was to create a therapeutic burn lotion that might treat those symptoms with lidocaine, sodium dodecyl sulfate, and antibacterial chemical combinations of camomile oil, hydrogen peroxide, and ethyl alcohol. After an emulsion lotion base was created with distilled water and olive oil, the other ingredients were added in sequence and mixed thoroughly to be homogenized. And, the burn injury lotion was tested for moisturization capability, pain-killing strength, blister reduction, and antibacterial strength.

As a result, the microscopic observations demonstrated the emulsion morphology of our burn lotion was good by being evenly distributed with spherical forms. Its relative viscosity was comparable to other commercial lotions. The moisturization ability was confirmed by the minimal weight change in mung bean jelly test. The skin sensations from the light and touch reflex test were reduced using Lumbricus terrestris, and the blister reduction capability was confirmed with the cabbage incubation test. At the same time, its antibacterial strength was verified with the zone of inhibition test using three types of bacteria such as Bacillus subtilis, Rhodospirillum rubrum, and Micrococcus luteus. The study demonstrated that our burn lotion might work effectively for the patient of burn injury.

Antibacterial strength, blister reduction, burn injury, burn lotion, pain relieving ability.

Article Details

How to Cite
CHOI, Y., & LEE, J. (2021). INVESTIGATING THE FORMULATION OF NEW THERAPEUTIC LOTION FOR BURN INJURY. Journal of International Research in Medical and Pharmaceutical Sciences, 16(2), 23-32. Retrieved from
Original Research Article


Kun Zou, Persephone M. Wynn, Philip Miller, Paul Hindmarch, Gosia MajsakNewman, Ben Young, Mike Hayes, Denise Kendrick. Preventing childhood scalds within the home: Overview of systematic reviews and a systematic review of primary studies. Published by Burns. 2015;41(5):907-924.

Allison Marier, Yongling Tu, Stephen Lee. Fireworks-related deaths, emergency department-treated injuries, and enforcement activities during 2019. CPSC, Consumer Product Safety Commission; 2020.

Hanglin Ye, Suvranu De. Thermal injury of skin and subcutaneous tissues: A review of experimental approaches and numerical models. HHS. 2017;43(5):909-932.

Judith E. Emergency medicine: A Comprehensive Study Guide (Emergency Medicine (Tintinalli)). New York: McGraw-Hill Companies. 2010;1374–1386.

Emillia C. O. Lloyd, Michael Michener, Michael S. Williams. Outpatient Burns: Prevention and Care. Am Fam Physician. 2012;85(1):25-32.

“Burns” WebMD; 2020.

Zawn Villines. Second-degree burn: Everything you need to know. MedicalNewsToday; 2019.

April Khan. Burns: Types, Symptoms, and Treatments and More. Healthline; 2019. Available:

Roberto Gianfaldoni, Serena Gianfaldoni, Jacopo Lotti, Georgi Tchernev, Uwe Wollina, Torello Lotti. The Importance of First Aid of Burned Patients: 30 Years of Experience at the Burns Centre in Pisa. Open Access Maced J Med Sci. 2017;5(4):420-422.

ISBI Practice Guidelines Committee, Steering Subcommittee, Advisory Subcommittee, “ISBI Practice Guidelines for Burn Care. PubMed. 2016;42(5):953.

Kathleen Davis, FNP, "Causes of allergic reactions and rashes," MedicalNewsToday; 2020.

Jimmy Toussaint, Adam J. Singer. The evaluation and management of thermal injuries: 2014 update. CEEM. 2014;1(1):8-18.

Anne M. Lachiewicz, Christopher G. Hauck, David J. Weber, Bruce A. Cairns, David Van Duin. Bacterial infections after burn injuries: impact of multidrug resistance. Clinical Infectious Diseases. 2017;65(12):2130-2136.

Babar Ali, Naser Ali Al-Wabel, Saiba Shams, Aftab Ahamad, Shah Alam Khan, Firoz Anwar, Essential oils used in aromatherapy: A systematic review. Asian Pacific Journal of Tropical Biomedicine. 2015;5(8):601-611.

Khaki M, Mohammad Ali Sahari, Moshen Barzegar. Evaluation of antioxidant and antimicrobial effects of chamomile (Matricaria chamomilla L.) essential oil on cake shelf. Journal of Medicinal Plants. 2012;11(43): 9-18.

Jarved India. 25 Benefits of Chamomile Tea for skin, hair and health; 2019. Available:,is%20and%20see%20quick%20results

Cerner Multum, “Lidocaine topical”; 2020.

Henning Hermanns, Markus W. Hollmann, Markus F. Stevens, Philipp Lirk, Timo Brandenburger, Tobias Piegeler, Robert Werdehausen. Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review. British Journal of Anaesthesia. 2019;123(3): 335-349.

Schandra Purnamawati, Niken Indrastuti, Retno Danarti, Tatan Saefudin. The role of moisturizers in addressing various kinds of dermatitis: A review. CM&R. 2017;15(3-4): 75-87.

Iti Som, Kashish Bhatia, Mohd Yasir. Status of surfactants as penetration enhancers in transdermal drug delivery. Journal of Pharm Bioallied Sci. 2012;4(1):2-9.

Clara Seoyeun Ryu, Jongbin Lee. Investigating the formulation of a phytoncide atopic dermatitis lotion. Journal of International Research in Medical and Pharmaceutical Sciences. 2019;14(1):1-9.

Kheloufi N, Lounis M. Viscosity measurement using optical tracking of free fall in Newtonian fluid. Acta Physica Polonica A. 2015;128:123-127.