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The pre-clinical research has been done to get empirical date the real of negative effect of mercury that used in cosmetics (mercury face cream). This research used 24 animals Mus Musculus divided into 6 groups; Control group; Mercury group; Nanogold 5ppm; Nanogold 10 ppm; Nanogold 15ppm and Nanogold 20 ppm. After adaptation two weeks All animal treat by mercury face cream for a week, except control group. After this treatment, 4 class continuous by recovery with nanogold 5, 10, 15, and 20 ppm for 4 weeks. One group that call mercury group killed to investigate effect of mercury face cream. Mercury had cause damages of fibroblast and reduce collagen quantity in skin tissue at previous research. This research investigated haw impact mercury in face cream at brain cells and collagen quantity of brain tissue if mercury exposure in skin area. The treatment continuous with nano-gold face cream to recovery and reduce these damages. HE staining used to analysis brain cells condition and Van Gieson staining used to analysis collagen quantity. The conclusion that a week mercury exposure caused many damage of tissues including collagen tissue, brain cells and others connecting tissue in brain. Recovery for 4 weeks with nanogold at variance concentration (5, 10, 15, and 20 ppm) reduce brain damage, especially brain cells and collagen tissue step by step near normal condition. The role of concentration of nanogold was real. The increase nanogold concentration give recovery be better. The impact of this research nanogold sweet material to substitute mercury that very dangerous material in cosmetics. Nanogold in the future as the best material in cosmetics formulation.
Taufikurohmah, Titik, et al. Histology study: Pre-clinic test of nanogold in mus muscullus skin, at fibroblast proliferation and collagen biosynthesis. Chemistry and Materials Research. 2013;(3)5:55-60.
Taufikurohmah, Titik, et al. TEM Analysis of gold nanoparticles synthesis in glycerin: Novel savety materials in cosmetics to recovery mercury damage. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2014;5(1):397-407.
Han, Xiaoning, et al. Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in aduld mice. Cell Stem Cell; 2013.
Rizal, Syaiful. Perbedaan Gambaran histopatologi otak tikus wistar akibat paparan arus listrik ada media air tawar dan air laut. semarang : Program Pendidikan Sarjana Kedokteran, Fakultas Kedokteran Universitas Diponegoro; 2014.
Jacob W, Skovira, et al. Simulated aeromedical evacuation excerbates experimental brain injury. Neurotrauma. 2016; 33.
Rahayu, Masruroh, Kurniawan, Shahdevi Nandar and Anggraini, Dini Jatayu. The effect of beta glucan of saccharomyces cerevisae on the increase of the number of brain cells in Substantia Nigra Brain of Parkinson's Wistar Strain Rat(Rattus Norvegicus) Model Induced with Rotenone. MNJ. 2015;01(02):44-47.
Xian-Jian, Huang, et al. Acute temporal profiles of serum levels of UCH-L1 and GFAP and relationships to neuronal and astroglial pathology following traumatic brain injury in rats. Neurotrauma. 2015;32(16):1179-1189.
Paul J, McMahon, et al. Measurement of the glial fibrillary acidic protein and its breakdown products GFAP-BDP biomarker for detection of traumatic brain injury compared to computed tomography and magnetic resonance imaging. Journal of Neurotrauma. 2015; 32(8):527-533.
Linda, Papa, et al. GFAP out-performs s100beta in detecting traumatic intracranial lesions on computed tomography in trauma patients with mild traumatic brain injury and those with extra-cranial lesions. Journal of Neurotrauma. 2014;31(11):1815-1822.
James L, Spira, et al. The impact of multiple concussions on emotional distress, post-concussive symptoms, and neurocognitive functioning in active duty united states marines independent of combat exposure or emotional distress. Journal of Neurotrauma. 2014;31(22): 1823-1834.
Maxwell, William L. Damage to myelin and oligodendrocytes: A role in chronic outcame following traumatic brain injury? Brain Science. 2013;3(3):1374-1394.
Guarino, Alyx T and McKinnon, Randall D. Reprogramming cells for brain repair. New Brunswick, NJ 08903, USA : Neurosurgery, Rutgers-Robert Wood Johnson Medical School, 125 Patterson St. CAB 7084; 2013.
Mukandala, Gatambwa, et al. The effects of hypoxia and inflammation of synaptic signaling in the CNS. Brain Science. 2016;6(1):6-14.
Basavarajappa, Balapal S. Fetal alcohol spectrum disorder: Potential role of endocannabinoids signaling. Brain Science. 2015;5(4):456-493.
Pallocca, Giorgia, et al. Changes in miRNA expression profiling during neuronal differentiation and methyl mercury induced toxicity in human in Vitro models. Toxics. 2014;2(3):443-463.
Bourdineaud, Jean-Paul, et al. Effects of methyl mercury contained in a diet mimicking the wayana amerindians contamination through fish consumption: mercury accumulation, metallothionein induction, gene expression variations and role of the chemokine CCL2. 6, Int. Journal Mol Science. 2012;13(6):7710-7738.
Taufikurohmah, Titik, et al. Histology Study: pre-clinic test of nanogold in mus muscullus skin, at fibroblast proliferation and collagen biosynthesis. Chemistry and Materials Research. 2013;3(5):55-60.
Taufikurohmah, Titik, et al. Mercury exposure effects to skin tissue of mus muscullus at fibroblasts cell proliferation and collagen quantity. Research Journal of Pharmaceutical, Biological and Chemical Science. 2013;4(4):60-70.
Cormack DH. Effect of heavymetals on human rheumatoid synovial cell proliferation and collagen synthesis. Introduction to Histology. Philadelphia : J.B Lippincott Company. 2004;299-303.
Taufikurohmah, Titik, et al. Activity Test of nanogold for reduction of free radicals, a pre-assessment utilization nanogold in pharmaceutical as medicines and cosmetics. Journal of Materials Science and Engineering B. 2012;2(12):611-617.
Agnete, L, et al. Gold ions bio-released from metallic gold particles reduce inflamation and apoptosis and increase the regenerative responses in focal brain injury. Histochem Cell Biol Springer-Verlag. 2008;13(4):681-692.
Taufikurohmah, Titik, et al. Synthesis of Nanogold and stability test of this colloidal as essential material in drug, supplement and cosmetics. International Journal of Science and Research. 2014;3(5):60-63.
Taufikurohmah, Titik, et al. Proses pembuatan nanogold dan penggunaannya dalam kosmetik. Jakarta : Paten Indonesia-Dirjen Haki, Kemenkumham Indonesia; 2011.
Taufikurohmah, Titik, et al. Perubahan Histokimia hati dan ginjal mencit terpapar merkuri serta pemulihannya dengan nanogold. Jurnal Kimia Molekul. 2016;11(1):80-91.
Taufikurohmah, Titik, et al. Mercury exposure effects to skin tissue of mus muscullus at fibroblast cell proliferation and collagen quantity. Research Journal of Pharmaceutical, Biological and Chemical Science. 2013;4(4):60-70.
Taufikurohmah, Titik, et al. Histology study: Pre-clinic test of nanogold in mus muscullus skin, at fibroblast proliferation and collagen biosynthesis. Chemistry and Materials Research. 2013;3(5):55-60.
Taufikurohmah, Titik and Setiarso, Pirim. Analisis kandungan merkuri pada krem wajah yang beredar pada klinik kecantikan di Surabaya. Surabaya : Universitas Press. Seminar Nasional Kimia. 2012;112-120.
Taufikurohmah, Titik, et al. Activity test of nanogold for reduction of free radicals, a pre-assessment utilization nanogold in pharmaceutical as medicines and cosmetics. Materials Science and Engineering B. 2012;2(2):87-97.
Ji-Ae, P, et al. Gold nanoparticles fungtionalized by GD-complex of DTPA-bis(amide) conjugate of glutatione an MRI contrast agent. Bioorganic & medicinal Chemistry Letters. 2008;18(23):6135-6137.