Journal of Applied Physical Science International

N-(2-hydroxy-1-naphthaldehyde)-2-amino-6-nitrobenzothiazole, azomethine chelator was synthesised via reflux condensation reaction between 2-amino-6-nitrobenzothiazole and 2-hydroxy-1-naphthaldehyde, giving 77.7 % and 9.0 g yield. The study aims to explore the applied studies of Schiff base ligand and its Mn²⁺ and Co²⁺ coordination compounds in antimicrobial and antifungal inhibition and dye stuff. The azomethine chelator so produced was mixed with 2,2’-bipyridine and used in the synthesis of Mn(II) and Co(II) coordination compounds. The chelator and the coordination compounds gave different shades of colour, they generally dissolved in (CH₃)₂CHON (DMF) and (CH₃)₂SO (DMSO), but were completely insoluble in distilled water and had melting points in the range 280 ≥ 360 ^oC. The amine functional group of the compounds was observed between 1616 – 1642 cm^-1, while bands between 457 – 517 and 513 – 647 cm^-1 marked M-O and M-N coordination, respectively. The ultraviolet bands for the chelator around 254, 308 and 342 nm were caused by π → π* and ո → π* transitions. On the other hand, the complexes along with these ultraviolet bands, though with somewhat different shifts, had unique absorption bands in the visible region, which are due to d → d shifts. The data obtained at the end of the antibacterial screening indicates that the compounds showed good inhibitory action against some of the bacteria in the range of 02.0 – 09.0 mm. For the antifungi, it was between 06.0 - 25.0 mm. The dye study showed that the azomethine chelator intensely dyed the white fabric, giving it a yellow colour. The Co²⁺ metal complex also particularly dyed the white fabric intensely, on a scale of 1 – 5, their performance was given a value of 4. Thus, the compounds are seen as promising antimicrobial agents and dyestuffs. The study recommends the following: the studied azomethine-based chelator and its Mn and Co complexes should be subjected to a clinical trial to further ascertain their antimicrobial potential and for onward inclusion as active antimicrobial drugs. The single crystals of the compounds should be grown for x-ray crystallographic analysis of the complexes for the establishment of their definite geometries. Furthermore, the azomethine-based ligand and its coordination compounds should be prepared in large quantities and utilised as dye agents. In conclusion, the antimicrobial screening showed that the azomethine-based chelator and the complexes had good antibacterial and antifungi activities, and so, they are promising antibacterial and antifungal agents. Also, their dye study presented the compounds as good dyeing agents.