Zingiber officinale AND Andrographis paniculata INHIBITS SELECTED PATHOGENIC BACTERIA GROWTH

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JANET FUNMILAYO AKINSEYE
TOSIMILE OLA-AMUDA
BERNARD OLUWAPELUMI OLUBOYO
RICHARD YOMI AKELE
FUNMILAYO A. ADEWUMI

Abstract

Background: The emergence of antibiotic resistance bacteria in general practice has necessitated the search for other alternative and newer antibacterial agents that are mainly of natural sources. Previous studies have shown that Zingiber officinale (ginger) and Andrographis paniculata (king bitters) have several beneficial properties against pathogenic bacteria and other microbes and are being used locally.

Aim: The antibacterial properties of Zingiber officinale and Andrographis paniculata extracts against selected clinical bacteria were evaluated in comparison to previous routine antibiotics.

Materials and Methods: Different graded concentrations of solvents were used to extract the active components from the plant parts (0.05 g/ml, 0.1 g/ml and 0.2 g/ml and 0.4 g/ml) and subjected to antibacterial sensitivity test against Pseudomonas aeruginosa, Citrobacter freundii, Staphylococcus aureus, Escherichia coli, Salmonella spp and Klebsiella pneumoniae.

Results: The methanol and ethanol extracts of the two plants showed greater antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus at a concentration of 0.4 g/ml with varying sensitivities and resistance of other bacteria recorded against the extracts and other antibiotics, while the aqueous extracts of both plants generally had no significant inhibitory activity against the tested bacteria.

Conclusion: The methanol and ethanol extracts of ginger and king of bitters plants may therefore be a promising and safe bioactive antimicrobial alternative against the multi-drug resistant Pseudomonas aeruginosa and Staphylococcus aureus in wounds and skin infections.

Keywords:
Andrographis paniculata, antibacterial potential, extracts, multi-drug resistant, pathogenic bacteria, Zingiber officinale

Article Details

How to Cite
AKINSEYE, J. F., OLA-AMUDA, T., OLUBOYO, B. O., AKELE, R. Y., & ADEWUMI, F. A. (2020). Zingiber officinale AND Andrographis paniculata INHIBITS SELECTED PATHOGENIC BACTERIA GROWTH. Journal of Disease and Global Health, 1233(2), 60–65. Retrieved from http://www.ikprress.org/index.php/JODAGH/article/view/4894
Section
Original Research Article

References

Karuppiah P, Rajaram S. Antibacterial effect of Allium sativum cloves and Zingiber officinale rhizomes against multiple-drug resistant clinical pathogens. Asian Pac J Trop Biomed. 2012;2(8):597–601.

Wang S, Zhang C, Yang G, Yang Y. Biological properties of 6-gingerol; Net prod. Commun. 2014;9(7): 1027-30.

Azu N, Onyeagba R. Antimicrobial of extract of Allium Copa (Onions) and Zingiber bacillum subtitis. Int. J. Trop. Med. 2007;3:1-4.

Li F, Nitteranon V, Tang X, Liang J, Zhang G, Parkin KL, Hu Q. In vitro antioxidant and anti-inflammatory activities of 1-dehydro-6-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin. Food Chem. 2012;15; 135(2):332-7.

Aniel O, Mutyala L, Raja K. In vitro antibacterial activity in the extracts of Andrographis paniculata. International Journal of PharmTech Research. 2010;2:01.

Dada-Adegbola O, Lajide O, Ajayi B. Comparative study of antibacterial activity of juice, Acetone, Methanol and Ethanol Leaf extract of Andrographis paniculata (King of Bitters). Journal of Medical Research. 2014;3(1):006-012.

Parvataneni R, Koduru RL. Antimicrobial activity of the chloroform extracts of the root and the stem Andrographis paniculata Nees. Int. Res. J. Microbiol. 2010;1(2):37-39.

Khulbe K, Sati S. Antibacterial Activity of Boenninghausenia albiflora Reichb. (Rutaceae). Afr. J. Biotechnol. 2009;8(22): 6346-6348.

Ok S, Jeong W. Optimization of extraction conditions for the 6-Shogaol-rich extract from ginger (Zingiber officinale Roscoe). Preventive Nutrition and Food Sciences. 2012;17(2):166–171.

Zamani Z, Kohan HK, Kadiar M, Parvizzadeh M, Irani S, Sadeghi S, Iravani A. The effect of ginger extract on glycoproteins of Rajin cells. Pakistan Journal of Biological Sciences. 2014; 17(2):241-247.

Mohamedin A, Elsayed A, Shakurfow FA. Molecular effects and antibacterial activities of ginger extracts against some drug resistant pathogenic bacteria. Egypt. J. Bot. 2018;58(1): 133–143.

Ghareeb MA, Shoebl HA, Madkou HMF, Refaey LA, Mohamed MA, Saad AM. Antioxidant and cytotoxic activity of Tectona grandis linn leaves. International Journal of Phytophamacology. 2014;5(2): 143-157.

Arshad M, Shadab M. Zingiber officinale extract: Antimicrobial properties phytochemical screening, drug likeness and physicochemical studies. European Journal of Pharmaceutical and Medical Research. 2017;4(3):364-368.

Sundar S, Jayasree T, Ditya D, Sanjana J, Sowmya M, Jahnavi S. Antimicrobial activity of aminoglycoside antibiotics combined with clove and ginger. World Journal of Pharmacy and Pharmaceutical Sciences. 2015;4(6):1515-1524.

Gull I, Saeed M, Shaukat H, Aslam SM, Samra ZQ, Athar AM. Inhibitory effect of Allium sativum and Zingiber officinale extracts on clinically important drug resistant pathogenic bacteria. Annals of Clinical Microbiology and Antimicrobials. 2012;11(1):8-11.

Sebiomo A, Awofodu A, Awosanya A, Awotona Ajayi A. Comparative studies of antibacterial effect of some antibiotics and ginger (Zingiber officinale) on two pathogenic bacteria. Journal of Microbiology and Antimicrobials. 2011;3(1):18-22.

Das S, Anjeza C, Mandal S. Synergistic or additive antimicrobial activities of Indian spice and herbal extracts against pathogenic, probiotic and food-spoiler micro-organisms. International Food Research Journal. 2012;19(5):1185-1191.

Shalini VB, Narayanan JS. Antibacterial activity of Andrographis paniculata Neesagainst selective human pathogens. African Journal of Microbiology Research. 2015;9(16):1122-1127.

Kaushik P, Goyal P. Evaluation of various crude extracts of Zingiber officinale rhizome for potential antibacterial acitivity: a study in vitro. Advance Microbiol. 2011;1:7-12.

Monoharan S, Monoharan E. Medicinal and pharmacological properties of Andrographis paniculata Int. J. Bio. Mol. Biomed. 2013;3(2):1-12.