SYNTHESIS AND BIOLOGICAL ACTIVITIES EVALUATION OF NEW SUBSTITUTED 1,2,4,8-TETRAAZASPIRO[4.5]DEC-2-ENES

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HANY M. DALLOUL
KHALED A. EL-NWAIRY
ALI Z. SHORAFA
AHMED S. ABU SAMAHA

Abstract

A new series of 1,2,4,8-tetraazaspiro[4.5]dec-2-enes containing 1,2,4-triazole, piperidine and sulfonamide moieties have been synthesized from the reaction of 4-piperidone benzoylhydrazones having 1-methyl, 1-benzyl, and 1-isopropyl groups with appropriate nitrilimines. The microanalysis and spectral data (IR, 1H NMR, 13C NMR and MS) of the synthesized compounds are in full agreement with their molecular structure. The microbial features of the synthesized compounds were studied by a known method. Some of titled compounds exhibited significant antimicrobial activity on several strains of microbes.

Keywords:
Antimicrobial activity, nitrilimines, sulfonamide, 1,2,4,8-tetraazaspiro[4.5]dec-2-ene

Article Details

How to Cite
DALLOUL, H., EL-NWAIRY, K., SHORAFA, A., & ABU SAMAHA, A. (2018). SYNTHESIS AND BIOLOGICAL ACTIVITIES EVALUATION OF NEW SUBSTITUTED 1,2,4,8-TETRAAZASPIRO[4.5]DEC-2-ENES. Journal of Applied Chemical Science International, 8(4), 144-152. Retrieved from http://www.ikprress.org/index.php/JACSI/article/view/4126
Section
Original Research Article